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Comparative metabolism and stability of andrographolide in liver microsomes from humans, dogs and rats using ultra-performance liquid chromatography coupled with triple-quadrupole and Fourier transform ion cyclotron resonance mass spectrometry

Journal name:Rapid Communications in Mass Spectrometry
Document No.:DOI: 10.1002/rcm.6585
Document URL: http://onlinelibrary.wiley.com/doi/10.1002/rcm.6585/full
Date publication:7 May 2013



Andrographolide (AP) is a major active anti-inflammatory compound extracted from Andrographis paniculata Nees. The metabolism stability of AP is one of the key factors for its further development as a new drug candidate. In order to clarify the biotransformation of AP among species, a comparative investigation of its in vitro metabolic pathways in human, dog and rat liver microsomes was carried out.


EXPERIMENTAL. Materials. Andrographolide (AP) was purchased from Chengdu Herbpurify Co. Ltd. The purity of this standard reference was over 98% determined by high-performance liquid chromatography with ultraviolet-diode array detection (UV-DAD). ...

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